Liver Functions, Anatomy and Diseases

Liver Functions, Anatomy and Diseases Sandra Marais Nikita Wiggil Charne Scott Chante Wiese   Sue-May van der Westhuizen Stephanie Willows Contents (Jump to) Introduction The Anatomy and function of the Liver Definition and description of the disease Fatty Liver Disease Symptoms PATHOPHYSIOLOGY AND ETIOLOGY OF FATTY LIVER DISEASES: Treatment and prevention Introduction The Anatomy and function of the Liver Anatomy is the science of the structure and shape of entities. It is important for the knowledge of hepatic anatomy and surgery. The liver is one of the largest organs of the human body after the skin it is the second largest. The liver is the largest gland in the human body, with an average weight of 1500g. The transverse measurements ranges between 20 and 22,5cm, its vertical measurements (close to its right/lateral surface) between 15 and 17,5cm and its antero-posterior diameter between 10 and 12,5cm. Its measurement, from opposite the vertebral column, is reduced to roughly 7,5cm. It is found underneath the diaphragm -in the right upper abdomen, mid abdomen as well as in parts of the left upper abdomen. The shape of the liver generally has the form of a wedge or a prism. According to Synington the shape resembles that of a right-angled triangular prism with the right angle rounded off. Its base faces the right and its apex to the left, the colour of the liver is dark reddish brown it has a soft degree of density, it contains a large amount of vessels and is very brittle. In an adult, it is smaller than in a fetus. In the later (side) it contributes roughly one thirty-six of the body weight. In the former (side) it contributes roughly one-eighteenth of the body weight. The liver has three surfaces namely the superior (Facies superior), inferior (Facies inferior/ visceral surface) and posterior (Facies posterior). The posterior surface is divided from the superior surface by a sharp margin. The superior surface attaches itself to the diaphragm as well as the anterior abdominal by the falciform ligament (ligamentum falciform hepatis). The falciform ligament separates the liver into a right lobe (lobus hepatis dexter) and a left lobe (lobus hepatis sinister). The right lobe is larger than the left. Five fossae divide the inferior and posterior surfaces into four lobes. The fossae are arranged like the letter ‘’H’’. The left limb of the H is divided into what is known as the left sagittal fossa (fossa sagittalis sinistra/longitudinal fissure) consisting off the fossa of the umbilical vein and the fossa for the ductus venosus. The right limb of the H consists of the fossa for the gall-bladder (fossa vesicà ¦ felleà ¦) and th e fossa for the inferior vena cava (fossa venà ¦ cavà ¦). The two limbs of the H surfs as a transverse fissure- the porta (porta hepatis/transverse fissure). The superior surface is part of is part of the left and right lobe. This surface is convex. The middle part is found behind the xiphoid process and it makes contact with the abdominal wall. It is entirely concealed by peritoneum, with the exception of the line of attachment of the flaciform ligament. The inferior surface is concave. It is aimed downward, backward as well as to the left. The surface is infused in peritoneum- the only parts that are without it, is where the gall-bladder and the liver attaches as well as at the porta hepatis. The posterior surface has a curved surface and is broad on the right, but narrow on the left. The diaphragm is attached with a triangular and coronary ligament that intertwine connective tissue, it leads to the intimate connection of the inferior vene cava that is connected with hapatic veins that holds up the posterior part of the liver. The abdominal viscera full the abdomen, where the muscular walls are in a state of tonic contraction. The superior surface of the liver fits under the diaphragm surface, so that the pressure is enough to hold the diaphragm. The lax falciform ligament creates no support for the lateral displacement and the latter creates negative pressure that is held up in the thorax (Gray, Henry. Anatomy of the Human Body. PHILADELPHIA: Lea Febiger, 1918; Bartleby.com, 2000. www.bartleby.com/107/. [DATE of Printout].) Functions of the liver The liver receives blood from two main sources: 30% is received from the hepatic arteries and 70% is received from the hepatic portal vein. The hepatic portal vein receives blood from the stomach, intestines, pancreas and spleen; which is then carried to the liver through the porta hepatis. All nutrients are absorbed by the small intestine, all nutrients reaches the liver by this route except for lipids. Arterial blood bound for the liver exists the aorta ant the celiac trunk. These arteries deliver oxygen and other materials to the liver. (SALADIN, p. 975-977) Digestion Liver produces bile; which is a mixture of water, bile salts, cholesterol and pigments of bilirubin. Bile is produced by hepatocytes in the liver. Bile passes through the bile ducts and is stored in the gallbladder. Fats are emulsificated by bile. Large fat clumps are turned into smaller pieces which makes it easy for the body to digest. Old worn oud red blood cells are destroyed by Kupffer cells in the liver. Kupffer cells pass their components to the hepatocytes. Haemoglobin is the red oxygen-carrying pigment of red blood cells, haemoglobin is metabolized into heme and globin components. Energy for the body comes from globin protein. Metabolism Liver is responsible for metabolizing carbohydrates , lipids and proteins into biologically useful materials. Blood entering the liver through the hepatic portal vein is rich in glucose from digested food. Some of this glucose is absorbed by hepatocytes. The glucose is stored as the macromolecule glycogen. Homeostasis is maintained by the absorption and release of glucose by the hepatocytes, it helps protect the body from spikes and drops that can be dangerous in the blood glucose level. Hepatocytes absorb and metabolise fatty acids to produce energy in the form of ATP. Through gluconeogenesis the hepatocytes convert glycerol and other lipid components into glucose. Cholesterol is a lipid which can also be produced by hepatocytes and gets excreted from the body as a component of bile. Amino acids is a component from dietary proteins. Amine groups are removed from the amino acids, by the hepatocytes, which is further converted into ammonia and urea. Urea can be excreted in urine as a waste product. Urea is less toxic than ammonia. Detoxification Hepatocytes cells of the liver monitor the contents of the blood and toxic substances are removed before they reach the rest of the body. Alcohol and drugs are metabolised into their inactive metabolites by the enzymes in hepatocytes cells. Storage Nutrients, vitamins and minerals obtained from the blood passing through the hepatic portal system are stored in the liver. Homeostasis of blood glucose is maintained by the storage of nutrients. Vitamins such as A, D, E, K and B12 is stored in the liver. Minerals such as iron and copper are stored in the liver. Production Vital protein components of blood plasma such as prothrombin, fibrinogen and albumins are produced by the liver. Prothrombin and fibrinogen proteins are factors involved in the formation of blood clots. Albumins maintain the isotonic environment of blood. Immunity Bacteria, fungi, parasites, worn out red blood cells and cellular debris are captured and digest by Kupffer cells. Large volumes of blood are cleaned very quickly by Kupffer cells due to the large volumes of blood passing through the hepatic portal system. (www.innerbody.com/image _digeov/card10-new2.html) American journal of Physiology: Gastrointestinal and Liver Physiology : physiology and pathophysiology of apoptosis in epithelial cells of the liver; pancreas and intestine. By Blake. A. Jones ; Gregory. J. Gores. Published 1 December 1997 (vol.273. no.6, G1174-G1188) Definition and description of the disease Fatty liver disease â€Å"Non-alcoholic fatty liver disease (NAFLD) is a clinical and pathological syndrome.† (Zeng, et al., 2008) The main feature of NAFLD is the swelling of the (liver cells) hepatocytes because of pathological factor, alcohol excluded, that injure the liver. NAFLD is ranged from fatty liver alone to steatohepatitis, steatonecrosis and non-alcoholic steatohepartitis (NASH). (NASH) is only a stage in non-alcoholic fatty liver disease. NAFLD may have the potential to progress into cirrhosis and liver failure.† Liver –biopsy features include steatosis, mixed inflammatory cell-infiltration, hepatocytes ballooning and necrosis, glycogen nuclei, Mallory’s hyaline and fibrosis.† (Angulo, 2002) According to Jansen (2004) NASH is an under diagnosed liver disease characterized by steatosis, necroinflammation and fibrosis. NASH can possibly develop into cirrhosis and hepatic cellular carcinoma. NASH incorporate mixed acute and chronic lobular inflammation, zone 3 perisinusiodal fibrosis and ballooning (Brunt, et al., 1999). Alcoholic liver disease. Alcoholic liver disease (ALD) includes a variety of spectrum of injury that can be from simple steatosis to frank cirrhosis. There are 3 groups of histological stages of ADL. Fatty liver or simple steatosis, alcoholic hepatitis and chronic hepatitis with hepatic fibrosis or cirrhosis. ALD can be caused by different types of factors including dose, duration and type of alcohol consumption and risk factors like obesity iron overload ect. Fatty Liver Disease Symptoms Non-alcoholic fatty liver disease causes no signs or symptoms that can be noticed but when it is noticed, it show signs of: Fatigue Pain in the right upper abdomen Weight loss. Inflammation and scarring of the liver Possible progression to liver failure. Symptoms consists of four (4) stages namely Simple fatty liver disease ( steatosis), Non-alcoholic Fatty liver Disease (NAFLD), Fibrosis And Cirrhosis. Simple fatty liver (Steatosis)- There are no clear symptoms and it can only be discoverd by an abnormal blood test result. Non-alcoholic Steotohepatitis (NASH)- It is the most aggressive form of this condition, it causes the liver to become inflamed creating a dull or aching pain in the top right abdomen, covering the lower side of the ribs. There may be no signs of any symptoms at all and it can only be discovered by specialized testing. Fibrosis- Constant inflammation in the liver which leads to the formation of scar tissue. Cirrhosis- Over a long period of time, it creates inflammation which can lead to the loss of liver function- which may lead to creating primary cancer. ALCOHOL-RELATED (ARLD) It shows no symptoms until the liver has already been severely damaged and it causes symptoms such as: Feeling sick, weak or tired Loos of weight Loss of appetite Jaundice- the yellowing of the eyes and skin The swelling of the stomach and ankles Confusion or drowsiness The excretion or the vomiting of blood. Alcohol related fatty liver disease is constantly diagnosed because of other conditions or other tests. PATHOPHYSIOLOGY AND ETIOLOGY OF FATTY LIVER DISEASES: Fatty Liver Disease encompasses two over head segments, namely Alcoholic Liver Disease and Non Alcoholic Liver Disease. ALCOHOLIC LIVER DISEASE (ALD) Alcoholic Liver Disease (ALD) encompasses the manifestations of the liver that is caused by the over consumption of alcohol (ethanol). It includes Fatty Liver, Alcoholic Hepatitis, and Chronic Hepatitis with liver cell fibrosis or cirrhosis.*1 Ethanol metabolization takes place in the liver. There are two main pathways of alcohol metabolism, namely alcohol dehydrogenase and cytochrome P-450 (CYP) 2 E1. The first pathway works as follows: Firstly ethanol is metabolized by Alcohol dehydrogenase (ADH) into Acetaldehyde in the cytoplasm. The second phase occurs in the smooth Endoplasmic reticulum of mitochondria, where Acetaldehyde is further metabolized by Aldehyde dehydrogenase into acetate. Acetate is then finally oxidized into carbon dioxide (CO2) and water. CYP 2E1 also converts ethanol into acetaldehyde (OShea, et al., 2010). Liver damage occurs in a few mutually related pathways: Acetaldehyde can form hybrid-adducts with reactive residues acting on proteins or small molecules, mediating lipid peroxidation and nucleic acid oxidation. (French, et al., 1984) During further metabolization of alcohol, Nicotinamide Adenine Dinucleotide (NAD) is reduced. This causes a shift in the NADH/NAD ratio. A higher NADH (reduced form of NAD) concentration increases the production of fatty acids, while lower concentrations of NAD result in decreased fatty acid oxidation. This altered ratio impair the metabolization of carbohydrates and lipids, resulting in the diversion from gluconeogenesis to ketogenesis and fatty acid synthesis. The liver cells compound the fatty acids to glycerol to form triglycerides. These accumulating triglycerides result in fatty liver. This leads to oxidative stress, which plays a pivotal role in ALD development. (French, et al., 1984) Furthermore, Acetaldehyde interacts through covalent binding with reactive residues of proteins found on the membranes of liver cells. This binding results in the formation of stable protein by-products which have been shown to be immunogenic. Tissue damage and ALD may be caused by this, because the neo-antigens may induce an immune reaction with anti-body production. CYP 2 E 1, when exposed to chronicle alcohol use generates free radicals through the oxidation of Nicotinamide Adenine Dinucleotide phosphate (NADPH) to NADP (OShea, et al., 2010). This exposure activates hepatic macrophages, also known as Kupffer cells, which leads to Tumor Necrosis factor-alpha (TNF-alpha). The production of reactive oxygen species (ROS) is increased by the mitochondria, which in turn was induced by the TNF-alpha. This also promotes oxidative stress, which leads to hepatocytes necrosis and apoptosis. Many alcoholics have a condition of malnutrition. The deficiency in anti-oxidants, such as vitamin E, only worsens the necrosis and apoptosis. Free radicals initiate the oxidative degradation of lipids, which causes inflammation and liver tissue becomes scarred. Although the over consumption of alcohol is the primary cause of ADL, it is not always a pre-requirement for ALD development. It is important to understand the mechanisms of liver damage. When liver cells are exposed to alcohol, ATP synthesis is reduced and the activity of mitochondrial complexes is depressed. This causes energy metabolism of liver cells to be severely weaker and results in tissue damage. Metabolization of ethanol takes place in the centrilobular area of the liver lobule. Hypoxia alters energy metabolism, therefore centrilobular hypoxia can also be responsible for liver injury. The pathophysiology of alcoholic liver disease is very complex and further in depth investigation to understand the disease and how to treat it is being done. NON-ALCOHOLIC FATTY LIVER DISEASE (NAFLD) Non-Alcoholic Fatty Liver Disease is an over arching term for a variety of conditions associated with fat depositions in liver cells. NAFLD ranges from Simple fatty liver to nonalcoholic steatohepatitis (NASH), to fibrosis and cirrhosis. The first stage of NAFDL is simple fatty liver or steatosis. It is considered harmless and only consists of a fat build up in the liver. The second stage, Nonalcoholic steatohepatitis is more serious, but not many individuals progress to this state from simple fatty liver. Two liver insults may lead to the development of NASH. With the first insult or hit, macro-vesicular steatosis (abnormal retention of lipids within a cell) occurs as a result of an excessive amount of triglycerides accumulating in the liver. The cause of triglyceride accumulation can result from excessive importation of free fatty acids from adipose tissue.*5 The accumulating lipids in the liver cells seem to be caused by insulin resistance. Insulin resistance leads to changes in the livers enzymatic pathways that control free fatty acid uptake, synthesis, degradation and the secretion of free fatty acids. A crucial paradox arises: the liver maintains its liver lipid metabolization, but carbohydrate metabolism is weakened or damaged. Hepatic steatosis caused by these factors can result into diminished hepatic free fatty acid oxidation, more hepatic lipogenesis or fewer lipids are secreted from the liver. Along with insulin resistance, obesity plays an important role in the development of NAFLD. These alterations make the liver sensitive for the second insult or hit, which is an inflammatory response and further liver damage (Carey, et al., 2013). Toxic inflammatory proteins are secreted by the cytokines in the liver.*6 Hepatocyte apoptosis, an organized form of cellular death, is a leading component of the second insult of NAFLD progression. Oxidative stress and resulting lipid peroxidation are involved in the progression of NAFLD to NASH. The term â€Å"oxidative stress† is frequently used to describe the imbalances in redox couples. *7 This metabolic reaction produce too much reactive free radicals called reactive oxygen species (ROS). This process usually occurs in the mitochondria. Lipid peroxidation can lead to changes in the cell membrane fluidity and these alterations cause tissue damage. Fibrosis is the third stage of NAFLD. NASH develops to form fibrosis if it is not treated. Fibrosis occurs where chronicle inflammation in the liver results in the formation of fibrous scar tissue around hepatic cells and blood vessels. The liver still functions normally, because there is still enough healthy tissue. The forth and most severe stage of NAFLD is cirrhosis. During this stage lots of scar tissue develops. This causes the liver to shrink and change morphologically. The damage caused by cirrhosis is permanent and cannot be saved or reversed. The progression of cirrhosis is slow, but it ultimately causes the liver to stop functioning.*8 Treatment and prevention Basic therapy: you have to work out a strategic plan of the intake of calories and adjustment of diet constitution. Medium aerobic exercise and the changing of some life styles and behaviour. Weight reduction: The most important fact of weigh reduction is not the amount of weight loss but how the weight is lost. Losing weight rapidly may increase portal inflammation and fibrosis. A relatively safe goal is to lose about 1.6kg per week. Liver transplantation: For some patients liver transplantation is recommended. Metabolic states should be examined before the transplantation. A BMI >40kg lm2 is a contrain dication (Zeng, et al., 2008) Abstinence: This is a very important therapeutic intervention for patients that have ALD. Abstinence helps to decrease portal pressure and lower progression to cirrhosis.

The Benefits to Society of Information Technology :: Exploratory Essays Research Papers

The Benefits to Society of Information Technology Information technology has had a great influence in our lives. Innovations such as television, internet, radio, cellular phones, etc., have influenced the way we teach, the way we shop, the way we maintain ourselves informed, and also the way we view sports. One of the oldest advancements in IT would be television. Television has brought sports to a whole new level. It has allowed people to view events across the country, and also to view events throughout the world. It is a great tool that allows the public to know what is happening as it happens. Television allows some of the most respected events to be viewed live, from our homes. A great example of this is the Super Bowl. The Super Bowl is now a tradition of American lives, and although it has been for many years, the first Super Bowl game was not as viewed by the country as it is now. Most people did not show the game the importance that they do now. With the help of technology the game could be viewed by millions of spectators and that made a big difference. Producers and marketers have managed to make the most out of it, to the point where even people who do not care about the game or the sport would watch it just for the commercials. Companies will air their best commercials d uring this event due to the high ratings that this event has. Broadcasters are also able to improve the viewing experience of sports events by providing fans with game-specific content when they want it. Team facts and game statistics give fans a closer view of the game. This ends to be beneficial to both the fans and the marketers; â€Å"it allows the fan to get closer to the game and the marketer to get closer to the fan.† (Sportvision) Television gets fans involved in the action, and puts the marketers in the broadcast. Another great advancement of information technology would be the use of the Internet. It is a powerful tool that is widely used to get information throughout the world. The greatest advantage about it is that many people have access to the Internet and information can easily be obtained whenever they want. It is one the fastest way to get information about your favorite sport. Information such as schedules, locations, last-minute scores, biographies of the players, purchasing of sporting goods as well as tickets could be done from ones home with the help of the Internet.

Case Study Analysis: The Need for Time Management Essay

According to Karen M. Williams, the â€Å"poor management of time will prevent a business from reaching its full potential† (1994, p. 1). Carl Robin’s case study is the perfect example of why time management is a crucial skill in the business world. Carl has been a campus recruiter for ABC Inc. for six months and recently hired fifteen new trainees who will work under the Operations Supervisor Monica Carrolls. Carl’s primary objective is to hold a new hire orientation; unfortunately, he let several key issues fall through the cracks and now it seems as though the orientation will not happen. Time management is extremely important and should have been used when coordinating recruitment activities. There are many arguments that could be made in this case study such as Carl being too new to his job to be in charge of the recruiting process, or that there should be more people involved in the effort overall. In this analysis a discussion will be made on the causal ch ain of problems that occurred because of Carl’s poor choices and inability to use his time wisely. As a result of Carl procrastinating and not using time management effectively, a causal chain of trouble was created. In order to fix this chain of trouble Carl must employ time management. Carl Robins was not prepared for leading the recruitment process. According to the case study, Carl is in a panic because his June 15th orientation is ruined because none of the elements are in place. If he was prepared to lead the recruitment process then he would have known to employ good time management skills. A little less than three months should have been enough time to coordinate the orientation and ensuring that all other issues are taken care of before the June 15th orientation meeting. Carl needed to be on top of all the different pieces that are involved in the recruitment process. Since call had only been employed for a few months, Carl did not know how to use good time management skills. This is a common  occurrence when time management is not used properly (Williams, 1994). Since Carl was new to the company he did not know that time management skills are necessary to complete each task in time for the orientation. There were several tasks that needed to be completed by Carl before the orientation in order for it to be a success. For example, Carl needed to create a training schedule and organize the orientation. Organization of the orientation included scheduling the meeting and ensuring that no other events were taking place in the training room during that time. He also had to put together manuals and policy booklets for trainees, and coordinate their physicals and drug tests. Carl also needed to make sure all these tasks were completed by trainees. He then had to ensure that each trainee’s transcript and application was on file prior to the orientation. None of these tasks were complete as of two weeks before the orientation date. Since Carl could not complete the tasks as required, the orientation will not be successful. The case study indicates that Carl procrastinated. Procrastination led to Carl not completing the required tasks in time. Procrastination can be a serious problem in the workplace which results in the need for â€Å"fires† to constantly be put out (Estroff Marano, 2003). Procrastination leads to people waiting until the last minute to attempt tasks. In this case, Carl looked into the tasks that needed to be completed only a couple weeks before the due date. There are numerous reasons that people procrastinate according to Kantra (2010). Some of the most common reasons for procrastination include the desire to avoid discomfort, or the need for perfection causes people to avoid doing a task; for example a person may decide to put off a task because they feel they can’t give 100% to the task (2010). Some people also suffer from self-doubt that they won’t be able to complete the task at hand; and there are some people who are just plain lazy (2010). In Carl’s case it is difficult to say with certainty what caused him to procrastinate as much as he did. As a new employee of the company it is possible that Carl suffered from self-doubt since he has never handled a recruitment event on his own. Regardless of the reason, it is evident that the reason none of the orientation tasks were not completed was because Carl procrastinated. Carl did not utilize his time well because he didn’t use time management. Carl should have used time management skills to ensure that all the orientation tasks were completed. By implementing time management skills Carl would havebeen able to better utilize his time. For example, he could have created a chart of what tasks needed to be completed and by when. Instead of waiting until the end to determine that drug tests and physicals were not complete, Carl could have informed trainees immediately what they needed to do and made arrangements for them to go to the clinic by the end of April. Another time management skill that would have helped Carl utilize his time better would be to review the existing policy and manual booklets within the first month to decide what was missing and fix them. The Operations Supervisor informed Carl of the various tasks that were needed by June 15th. This gave Carl an entire month to complete the above mentioned tasks and he assured his supervisor that everything would be completed; unfortunately, Carl was wrong. Carl did not utilize his time well because he didn’t use time management. Scheduling conflicts were also a problem in this case study. When Carl checked on some of the tasks at the end of May (after Memorial Day), nothing was completed and the training room was booked .Carl had not checked with the training room schedule to determine whether it was free on June 15th. As a result, another employee was using it for the entire month for his training class. This is a huge problem that could have been avoided if Carl had been better prepared. Carl should have double checked everything prior to the orientation to ensure that no last minute details were overlooked. Scheduling is a part of time management. Carl had a list of tasks that he needed to complete such as booking the orientation room. The orientation room was not available because of scheduling conflicts. This case study demonstrates conflicts of schedule. Carl should come up with an alternative plan of action. Carl was faced with the decision of whether he should just admit he failed and face the conseq uences of his actions, or make an attempt at fixing this problem. Carl will likely have to admit to his supervisor that he made many mistakes in coordinating the orientation since the supervisor will likely question any changes to the schedule. However, he should not give up, but rather come up with an alternative. An alternative plan is needed, which should have been a part of his process to begin with it. There should always be a plan B. Alternative solutions to Carl’s immediate problem are a few though. If Carl is to forge ahead in hopes of actually holding the orientation then he needs to move fast. He has approximately two weeks from the point he discovers the problems to the date  of the orientation. If he moves efficiently and uses effective time management skills, he should still be able to hold the orientation. Carl must create an alternative plan of action in order for the orientation to be held on time. Now that Carl knows there are major problems he must sit down and creatively come up with a plan. First, he must contact trainees and have them report to the clinic within the next 48 hours. This of course, is not ideal and would put a lot of pressure on the trainees, but it must be done. If for some reas on some of the trainees cannot do it within the 48 hour time frame, an extension could be made, but it cannot extend longer than the end of the first week. This is because he will need to have time to collect results, and take appropriate actions based on those results, which will take a few days. He must also contact the Human Resources department and get copies of all fifteen applications and transcripts. If they do not have copies, then Carl must contact the trainees and have them deliver them to him no later than at the end of the first week. During that first week, Carl must also search for an alternative room for the orientation. It might be possible to hold the orientation in another room within the company. Perhaps there is an auditorium or meeting room that can be used. Carl must be creative in order to create a plan. Once the most time consuming tasks are complete, Carl must address the policy and manual handbooks. This can be done in the second week to allow for the more important issues to be handled during the first week. This can be a fairly easy task. Any policy or manual documentation that isn’t available should be available at the Human Resources department. Once he receives the documents, he can copy the pages and then put them together. This is the final task that needs to be completed and can be accomplished in just a day. There is also always the possibility of moving the date of the orientation to after June when the orientation room would be available. This would also give Carl enough time to coordinate the various tasks that need to be completed. The problems that occur with this approach are that it is unprofessional and will give the company a bad impression of Carl, especially since this is his first attempt at recruiting. Also, Carl’s original plan was to get the trainees working by July. To move the orientation date into July would go against his original plan. Therefore, moving the date of orientation is not an acceptable alternate solution. As previously mentioned Carl’s options are limited. The  fact that he is new at this particular position calls for a quick and effective solution to the problem. His supervisor will know that something went wrong when she sees that the orientation loca tion has been moved. It is for this reason that Carl’s best choice is to admit he made a mistake, but then demonstrate that he has remedied that mistake effectively. When he approaches the supervisor about the mistake, he should have proof in hand of the new plan and all the completed tasks. The blame should not be entirely placed on Carl seeing as he is a new hire in his position of recruiter. As a new hire, he should have had someone assisting him through the steps of coordinating a new trainee orientation. There is also no mention of an employee handbook, or similar that would have helped him through the process. Having a partner or superior, as well as a manual for directions, is common in the workplace which is why it is surprising that these were not present in the case study. Perhaps the organization itself is not well organized. A large project such as the one Carl was working on calls for collaboration. Collaboration in an organization is of critical importance. As mentioned above, it was surprising that Carl did not have a superior to walk him through his first recruitment event. This does not mean, however, that Carl couldn’t have approach a fellow employee for assistance. If Carl had reached out to fellow employees, perhaps the tasks would have been completed on time through collaborative efforts. Research has shown that collaboration creates a flexible and productive workplace (Beyerlein, et al., 2003). It is unknown whether ABC Inc. fosters a collaborative environment; however, reaching out to coworkers for assistance in not usually frowned upon by management in most companies. Carl should have sought to collaborate on the recruitment project. Effective time management would have helped Carl complete each task and to recognize certain problems, such as the unavailable training room, prior to the June 15th deadline. Carl had an opportunity to demonstrate his recruitment skills for the first time and two weeks prior to the project deadline was faced with the fact that he might fail. Unfortunately none of the tasks were completed and the room was unavailable to him. The only appropriate choice was to attempt to get all tasks completed within the two week span before the orientation date. This is unprofessional and will  highlight his mistakes to his supervisor; however, it is better to fix the mistakes and then admit them, rather than to admit to the mistakes and not fix them at all. Effective time management skills would have helped Carl to successfully fulfill his recruitment event tasks. References Beyerlein, M.M., Freedman, S., McGee, C., and Moran, L. (2003). The Ten Principles of Collaborative Organizations. Journal of Organizational Excellence. Retrieved March 29, 2012 from http://courses.washington.edu/nutrmgmt/564_ArticlesUsed_07/Beyerlein_Teams_03.pdf Estroff Marano, H. (2003). Procrastination: Ten Things to Know. Psychology Today. Retrieved on March 14, 2012 from http://www.psychologytoday.com/articles/200308/procrastination-ten-things-know Kantra, D.S. (2010). Just Do It! Why People Procrastinate. PsychDigest. Retrieved March 29 2012 from http://psychdigest.com/just-do-it-why-people-procrastinate/ Williams, K.M. (1994). Tips on Effective Time Management. Ohio State University. Retrieved on March 14, 2012 from http://ohioline.osu.edu/cd-fact/1006.html

Nucleophile Definition

Definition: A nucleophile is an atom or molecule that donates an electron pair to make a covalent bond. Also Known As: Lewis base Examples: OH- is a nucleophile. It can donate a pair of electrons to the Lewis acid H to form H2O.